| Pair Name | (S)-10-Hydroxycamptothecin, Crizotinib | ||
| Phytochemical Name | (S)-10-Hydroxycamptothecin (PubChem CID: 97226 ) | ||
| Anticancer drug Name | Crizotinib (PubChem CID: 11626560 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | (S)-10-Hydroxycamptothecin, Crizotinib | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | CYCS | hsa54205 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Down-regulation | Phosphorylation | MAPK8 | hsa5599 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Up-regulation | Phosphorylation | MAPK14 | hsa1432 | |
| Down-regulation | Phosphorylation | EGFR | hsa1956 | |
| In Vitro Model | NCI-H1975 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1511 |
| HCC827 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_2063 | |
| NCI-H460 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0459 | |
| Result | Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells. J Enzyme Inhib Med Chem. 2023 Dec;38(1):1-11. doi: 10.1080/14756366.2022.2132487. | Click |
